INDEPENDENT Age: 73 Director Since: 2014 Committees: Nominating and Governance Committee (Chair) and Science and Technology Committee Dr. Widder has more than 30 years of experience working with biomedical companies. Dr. Widder previously served as the Executive Chair of OrphoMed Inc., a clinical-stage biopharmaceutical company, from 2017 to 2022, and was a founder, chair and Chief Executive Officer of Sydnexis, Inc., a private company developing low dose atropine for the treatment of myopia progression in children, from 2017 to 2022. Dr. Widder was a General Partner with LVP Life Science Ventures, a venture capital company for biotechnology and medical device start-ups, from 2007 to 2016. Dr. Widder holds an M.D. from Northwestern University and trained in pathology at Duke University. Dr. Widder has more than 30 years of experience leading and investing in biomedical companies. Dr. Widder also has a strong governance background through his service on the boards of directors of several other companies. As a medical doctor trained in pathology, Dr. Widder also provides valuable insight into the Company s research pipeline, strategic direction and marketing position from the perspectives of both an executive and a physician. Other Current Public Company Directorships: Personalis, Inc. Audit Committee and Nominating and Corporate Governance Committee Prior Public Company Directorships Within the Past 5 Years: Evoke Pharma, Inc. until December 2025